Abstract #0412

SPINAL CORD SODIUM AND AXONAL LOSS IN MULTIPLE SCLEROSIS

Bhavana Shantilal Solanky¹, Ferran Prados ², Carmen Tur¹, Sebastien Ourselin², Xavier Golay³, Olga Ciccarelli¹, and Claudia A M Gandini Wheeler-Kingshott^1,4,5

¹UCL Institute of Neurology, Queen Square MS Centre, University College London, London, United Kingdom, ²Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ³UCL Institute of Neurology, University College London, London, United Kingdom, ⁴Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁵Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy

Increased sodium concentration in the normal appearing brain of multiple sclerosis (MS) patients has recently been reported, which may be a consequence of axonal loss or an accumulation of intracellular sodium. Here we investigated spinal cord total sodium concentrations in MS patients and healthy controls. Spinal cord atrophy, as a result of axonal loss, often presents in MS, therefore we also tested for the association of sodium with SC area. We found increased total sodium levels in the SC, but no correlation with the decrease in SC cross sectional area in the MS cohort.

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