Diffusion weighted spectroscopy enables investigation of brain intracellular microstructure in-vivo. Here we implemented a novel technique called diffusion-weighted echo-planar J-resolved spectroscopic imaging (DW-EPJRESI) which is capable of giving information about metabolite diffusivity beyond NAA, Cr and Cho in multiple brain locations simultaneously. The technique was evaluated in a brain phantom and four healthy volunteers. Highly reproducible diffusion-weighted metabolite maps were obtained. The ADC values were in good agreement with previous reported values. Further optimization of the DW-EPJRESI sequence will become more practical for clinical use.
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