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Abstract #0402

Functional Magnetic Resonance Spectroscopy (fMRS) using metabolite cycled semi-LASER at 9.4T: a pilot study

Ioannis-Angelos Giapitzakis1,2, Nikolai Avdievitch1, Saipavitra Murali Manohar1, Nicole Fichtner3,4, Roland Kreis 3, and Anke Henning1,5

1High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Graduate School of Neural and Behavioural Sciences, Tuebingen, Germany, 3Departments of Radiology and Clinical Research, University Bern, Bern, Switzerland, 4Institute for Biomedical Engineering, UZH and ETH Zurich, Zurich, Switzerland, 5Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany

The purpose of this work is to explore the potentials of fMRS under a visual stimulation at 9.4T using a metabolite cycled (MC) semi-LASER sequence. The MC technique allows for simultaneous acquisition of water and metabolite spectra enabling the synchronous investigation of dynamic alternations of BOLD signal and metabolite levels. Correlation of FWHMCr and FWHMNAA with SNRwater is demonstrated. The influence of misaligned subtraction is evaluated and the requirement of linewidth, frequency and phase-correction is highlighted. Finally, all previously reported alterations of upfield metabolites are confirmed and for first time also potential difference of downfield metabolites are observed.

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