Abstract #0387

Whole Brain Inversion Recovery Diffusion Weighted Imaging Using Slice-Shuffled Acquisition

Hua Wu¹, Qiyuan Tian^2,3, Christian Poetter¹, Kangrong Zhu², Matthew J Middione⁴, Adam B Kerr², Jennifer A McNab³, and Robert F Dougherty¹

¹Center for Cognitive and Neurobiological Imaging, Stanford University, Stanford, CA, United States, ²Department of Electrical Engineering, Stanford University, Stanford, CA, United States, ³Department of Radiology, Stanford University, Stanford, CA, United States, ⁴Applied Sciences Laboratory West, GE Healthcare, Menlo Park, CA, United States

Combined acquisition of diffusion weighted MRI and T1 relaxation allows us to extract information about the microstructures of human brain on a sub-voxel level. We design an inversion recovery pulse sequence with diffusion weighting using the slice-shuffled technique to accelerate the T1 measurement and demonstrate whole brain scans acquired in under 20 minutes. We show potential applications of the sequence in differentiating the T1 relaxation of compartments with different diffusion properties within a voxel .

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