Abstract #0371

Accuracy and Reproducibility of Iron Quantification using Ultra-Short TE Imaging at 1.5T and 3.0T

Curtis N Wiens¹, Ante Zhu^1,2, Kevin M Johnson^1,3, Scott B Reeder^1,2,3,4,5, and Diego Hernando^1,3

¹Radiology, University of Wisconsin, Madison, WI, United States, ²Biomedical Engineering, University of Wisconsin, Madison, WI, United States, ³Medical Physics, University of Wisconsin, Madison, WI, United States, ⁴Medicine, University of Wisconsin, Madison, WI, United States, ⁵Emergency Medicine, University of Wisconsin, Madison, WI, United States

This work examined the accuracy and reproducibility of ultra-short TE (UTE) R2* mapping in patients with liver iron overload. Fifteen subjects with known or suspected liver iron overload were scanned at 1.5T and 3.0T using a radial UTE, two Cartesian multi-echo, gradient-echo acquisitions, and an R2-based (FerriScan) reference acquisition. UTE R2* measurements demonstrated excellent reproducibility across field strengths (with expected linear increase with field strength) and high correlation with liver iron concentration. Cartesian approaches offered excellent reproducibility for R2*<1000s^-1. However R2*>1000s^-1, neither Cartesian approach were reproducible across field strength, suggesting that the range of R2* had been surpassed.

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