Abstract #0355

Measurements of Oxygen Delivery and Consumption Using Hematocrit Derived from Blood T1 Quantification

Feng Xu^1,2,3, Wenbo Li^1,2, Peiying Liu^1,2, Hanzhang Lu^1,2, John J. Strouse⁴, James J Pekar^1,2, Peter C.M. van Zijl^1,2, and Qin Qin^1,2

¹F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ²The Russell H. Morgan Department of Radiology and Radiology Science, Johns Hopkins University, Baltimore, MD, United States, ³Developing Brain Research Laboratory, Children's National Medical Center, Washington DC, DC, United States, ⁴Department of Medicine, Duke University, Durham, NC, United States

We verified that venous blood T1 quantified in vivo in humans using fast and non-invasive MRI can be used to derive hematocrit (Hct) values reliably. This Hct information can be used for a more individual estimation of oxygen extraction fraction (OEF) from venous blood T2 measurements. Furthermore, inverse correlation between Hct and baseline cerebral blood flow (CBF) was observed across subjects. Measurement of Hct, OEF and CBF allowed determination of oxygen delivery (OD~CBF∙Hct) and consumption (cerebral metabolic rate of oxygen, CMRO₂~CBF∙Hct∙OEF). When compared to CBF, OD and CMRO₂ showed less inter-subject variations among normal volunteers.

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