Abstract #0337

Noninvasive Functional Evaluation of Coronary Stenosis Using MR Instantaneous wave-Free Ratio (MR-iFR): Pilot patient study using invasive fractional flow reserve as a reference

Zixin Deng^1,2, Sang-Eun Lee³, Zhaoyang Fan¹, Christopher Nguyen¹, Yibin Xie¹, Jianing Pang¹, Xiaoming Bi⁴, Qi Yang¹, Byoung-Wook Choi⁵, Jung-Sun Kim³, Daniel Berman¹, Hyuk-Jae Chang³, and Debiao Li¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Cardiology, Severance Cardiovascular Hospital, ⁴Siemens Healthcare R&D, ⁵Radiology, Severance Cardiovascular Hospital

In patients with suspected coronary artery disease undergoing invasive coronary angiography, approximately half has nonsignificant stenosis (stenotic lesions that may not induce ischemia), leading to frequent and unnecessary invasive procedures. Previously, we proposed a noninvasive technique for functional evaluation of coronary stenosis using PC-MRI and navier-stokes equations. In this study, we evaluated the feasibility of the technique in patients, using invasive fractional flow reserve as a reference. Good correlation was observed between noninvasive and invasive techniques with high specificity and negative-predictive-value, demonstrating the potential of the proposed technique in identifying patients with functionally nonsignificant stenosis and eliminating unnecessary invasive procedures.

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