We demonstrate the preliminary clinical feasibility and utility of a 3D non-Gadolinium MR angiography sequence called REACT (Relaxation-Enhanced MR Angiography without Contrast and Triggering) in 21 pediatric patients (age range: 1.7 – 16.1 years). REACT, which collectively utilizes T2-preparation, inversion recovery, and water-fat separation to suppress unwanted signals and exploit the long T1 and T2 times of unenhanced blood, is particularly beneficial in children, a population where Gadolinium administration should be minimized given recent concerns with residual intracranial Gadolinium deposition. We illustrate and compare REACT to Gadolinium-based MRA in the neck, upper and lower extremities, and the chest, abdomen, and pelvis.
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