Ischemia in a mouse stroke model was assessed by pH mapping using the on-resonance variable-delay multi-pulse (onVDMP) CEST scheme. In the method, an on-resonance binomial pulse train is applied at the water resonance to achieve high labeling efficiency for fast-exchanging protons. Since the CEST signal intensity for the total fast-exchanging protons is far greater than that of amide protons, high detection sensitivity is expected. The final stroke region determined by the method was verified by histologic analysis.
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