Abstract #0268

ASPECTS Based Reperfusion Status on Arterial Spin Labeling Is Associated with Clinical Outcome in Acute Ischemic Stroke Patients

Samantha J. Ma¹, Songlin Yu², David Liebeskind³, Dandan Yu⁴, Ning Li⁵, Xingfeng Shao¹, Jeffrey Saver⁶, Noriko Salamon⁷, and Danny JJ Wang¹

¹Neurology, University of Southern California, Los Angeles, CA, United States, ²Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China, ³Neurovascular Imaging Research Core and Department of Neurology, UCLA, Los Angeles, CA, United States, ⁴Neuro-Intensive Care Unit, Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China, ⁵Biomathematics, UCLA, Los Angeles, CA, United States, ⁶Neurology, UCLA, Los Angeles, CA, United States, ⁷Radiology, UCLA, Los Angeles, CA, United States

An automatic scoring system for assessing reperfusion status based on arterial spin labeled (ASL) perfusion MRI was developed and evaluated for acute ischemic stroke patients who received thrombolysis and/or endovascular treatment. Reperfusion injury is considered to have the same detrimental effects as non-reperfusion, and we applied the ASPECTS model to address the existence of heterogeneity of hypo- and hyper-perfusion despite vessel recanalization. Our newly devised reperfusion scoring system is highly associated with patient functional outcome and provides a useful tool to complement other clinical methods for managing corresponding strategies after treatment.

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