Abstract #0257

Radiogenomics of 201 WHO grade 2 and 3 gliomas

Manabu Kinoshita^1,2, Hideyuki Arita², Masamishi Takahashi³, Yoshitaka Narita³, Yuzo Terakawa², Naohiro Tsuyuguchi², Yoshiko Okita², Masahiro Nonaka², Shusuke Moriuchi², Junya Fukai², Shuichi Izumoto², Kenichi Ishibashi², Yoshinori Kodama², Kanji Mori², Koichi Ichimura³, and Yonehiro Kanemura^2,4

¹Neurosurgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan, ²Kansai Molecular Diagnosis Network for CNS Tumors, Osaka, Japan, ³National Cancer Center Hospital, Japan, ⁴Osaka National Hospital, Osaka, Japan

Genetic alterations found in WHO grade 2 and 3 gliomas include IDH1/2 and TERT promoter mutations and 1p19q co-deletion. In this research, the authors attempted to test the hypothesis that genetic alterations could contribute to the locations and texture of the tumor by analyzing 201 WHO grade 2 and 3 gliomas using radinogenomic analysis. The authors were able to confirm the hypothesis that genetic alterations do contribute to the locations and textures of the tumor. 15 radionomic features were identified and those features were able to identify 3 genetic subgroups of WHO grade 2 and 3 gliomas.

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