We analysis subcortical nucleus volume and shape alterations in a relatively large sample of drug-naive adult patients with Obsessive-Compulsive disorder by using an automatically segmentation and vertex-based shape analysis protocol. Our findings indicated that (i)Gender effects were found in OCD, male patients seems are affected in reward system whereas females might have more disrupted stratum-pallidum-thalamus pathway which might be related to chronic stress. (ii)Shape analysis may provide more anatomical change information from a different perspective. Future structural research should consider shape and volume alterations together when explore brain changes.
This abstract and the presentation materials are available to members only; a login is required.