Abstract #0220

High Spatial Resolution Mapping of Trans-Capillary Water Exchange in Progressive Multiple Sclerosis

Ian Tagge¹, Manoj Sammi¹, Rebecca Spain², Dennis Bourdette², Randy West², John Grinstead^1,3, Katherine Powers¹, Xin Li¹, Charles Springer¹, and William Rooney¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Neurology, Oregon Health & Science University, Portland, OR, United States, ³Siemens Medical Solutions, Portland, OR

DCE-MRI data were acquired from 14 healthy control (HC) and 16 secondary progressive multiple sclerosis subjects on a 7T MRI instrument to investigate difference in brain blood vessel properties. The Shutter-Speed Paradigm was used to map blood volume fraction and trans-capillary water exchange kinetics. Our finding suggest abnormalities in brain blood vessel properties suggestive of impaired metabolism in secondary progressive MS.

This abstract and the presentation materials are available to members only; a login is required.

Join Here