Abstract #0206

Full Brain Vasculature Analysis using Gradient/Spin-Echo Multi-band EPIK: Tumour Evaluation with MR-PET

Nuno André da Silva¹, N Jon Shah^1,2,3, Rute Lopes^1,4, Ezequiel Farrher¹, and Seong Dae Yun¹

¹Institute of Neuroscience and Medicine - 4, Forschungszentrum Jülich, Jülich, Germany, ²Department of Neurology, Faculty of Medicine, RWTH Aachen University, JARA, Aachen, Germany, ³Department of Electrical and Computer Systems Engineering, and Monash Biomedical Imaging, School of Psychological Sciences, Monash University, Melbourne, Australia, ⁴Institute of Biomedical Engineering and Biophysics, Science Faculty of University of Lisbon, Lisbon, Portugal

Perfusion weighted imaging (PWI) using dynamic susceptibility contrast (DSC) imaging is a widely used technique in tumour imaging. The use of multi-echo DSC, gradient and spin echo (GESE), allows one to obtain vasculature information. However, trade-off between number of echoes, spatial resolution and brain coverage is required. In this work, the use of EPI with keyhole (EPIK) combined with multi-band is proposed to obtain a whole brain multi-echo GESE-DSC in clinically relevant acquisition times. The method was applied in a cohort of brain tumour patients in a MR-PET scanner enabling localisation of the tumour based on metabolic information from PET.

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