Abstract #0168

Hyperpolarized 13C Magnetic Resonance Evaluation of Renal Ischemia Reperfusion Injury in a Murine Model

Celine Baligand¹, Hecong Qin², Aisha True-Yasaki², Jeremy W. Gordon², Cornelius VonMorze², Justin DeLos Santos², Joy P. Walker³, David M. Wilson², Robert L. Raffai³, John Kurhanewicz², David H. Lovett⁴, and Zhen J. Wang²

¹Department of Radiology, Leiden University Medical Center, C.J. Gorter Center for High-field MRI, Leiden, Netherlands, ²Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ³Department of Surgery, University of California San Francisco, San Francisco, CA, United States, ⁴Department of Medicine, University of California San Francisco, San Francisco, CA, United States

Persistent oxidative stress and mitochondrial dysfunction have been implicated across diverse forms of acute kidney injury and in the transition to chronic kidney disease. We show that HP ¹³C metabolic MR can be used to noninvasively assess the altered renal redox capacity and mitochondrial PDH activity following ischemic reperfusion injury. Such an imaging approach can potentially enhance the prediction and monitoring of progressive kidney injury.

This abstract and the presentation materials are available to members only; a login is required.

Join Here