Abstract #0162

Chemical Shift Imaging of pH with Hyperpolarized [2-13C,D10] Diethylmalonic Acid

David Korenchan^1,2, Celine Taglang¹, Cornelius von Morze¹, Joseph Blecha¹, Jeremy Gordon¹, Peder Larson^1,2, Henry VanBrocklin¹, John Kurhanewicz^1,2, David Wilson¹, and Robert Flavell¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Bioengineering, University of California, Berkeley, Berkeley, CA, United States

Imaging tumoral pH may aid in characterizing aggressiveness, metastasis, and therapeutic response. The study of hyperpolarized (HP) ¹³C chemical shift-based probes addresses some of the limitations of previously reported ratiometric methods, including HP ¹³C bicarbonate. We report the development of HP [2-¹³C,D₁₀] diethylmalonic acid as a pH imaging agent, which exhibits a significant ¹³C chemical shift difference over the physiologic pH range. We demonstrate that this compound can be copolarized with tert-butanol to accurately measure pH in phantom studies. Furthermore, this HP compound showed high in vivo SNR in a murine model of prostate cancer.

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