Abstract #0150

Saccular intracranial aneurysm wall permeability and shear stress distribution: a further insight into rupture pathogenesis

Xian Liu¹, Yu Chen¹, Haikun Qi¹, Peng Liu², Yunduo Li¹, Xiaole Wang¹, Le He¹, Qiang Zhang¹, Zhensen Chen¹, Rui Li¹, Youxiang Li², Chun Yuan³, and Huijun Chen¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, People's Republic of China, ²Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China, ³Department of Radiology, University of Washington, Seattle, WA, United States

The purpose of this study is to explore the relationship between aneurysm wall permeability and the hemodynamic conditions of intracranial aneurysm (IA). The results showed that hot spot of IA wall permeability was spatially related with significantly lower wall shear stress magnitude and higher oscillatory shear index, which suggests the pathology of IA might be an interaction of both factors, and IA wall permeability could be a potential method for IA rupture risk assessment.

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