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Abstract #0147

Analysis of cerebrovascular watershed areas in patients with high-grade carotid artery stenosis using DSC-based time-to-peak maps

Vanessa Griese1, Stephan Kaczmarz1, Anne Kluge1,2, Kim van de Ven3, Michael Helle4, Hendrik Kooijman-Kurfuerst4, Claus Zimmer1, Christian Sorg 1,5, Jens Göttler1, and Christine Preibisch1,5,6

1Neuroradiology, Technical University of Munich, Munich, Germany, 2Radioonkology and Radiotherapy, Charité Berlin, Berlin, Germany, 3Philips Healthcare, Best, Netherlands, 4Philips Research, Hamburg, Germany, 5TUM Neuroimaging Center (TUM-NIC), Technical University of Munich, Munich, Germany, 6Neurology, Technical University of Munich, Munich, Germany

Internal carotid artery stenosis (ICAS) is one of the leading causes for thromboembolic and hemodynamic cerebral infarction. Here, we present data from an ongoing clinical MRI-study in patients with asymptomatic, high-grade ICAS and healthy controls. Our major aim was to establish a method to delineate individual watershed areas in patients and controls using MRI-based dynamic susceptibility contrast (DSC) time-to-peak (TTP) maps, also including the anatomical information of magnetic resonance angiography (MRA) to define individual vascular territories. Watershed areas were enlarged and shifted in many of the vascular territories of stenosed carotid arteries, being verified by ss-pCASL in a subgroup.

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Abstract