Abstract #0132

Dictionary approach to partial volume estimation with MR Fingerprinting: Validation and application to brain tumor segmentation

Anagha Deshmane¹, Debra McGivney², Chaitra Badve³, Vikas Gulani^2,3, and Mark Griswold²

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Radiology, Case Western Reserve University, Cleveland, OH, United States, ³Radiology, University Hospitals, Cleveland, OH, United States

MR Fingerprinting signal evolutions can be used to estimate partial volumes of tissues in addition to tissue relaxation times. Two approaches to tissue fraction estimation, a pseudoinverse calculation and dictionary-based or constrained solution, are quantitatively compared in the presence of four potential error sources. The constrained approach is found to more accurately estimate tissue fractions, and also to improve segmentation of pathology.

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