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Abstract #0119

5D MRI for late enhancement dynamics in lung fibrosis

Maria Teodora Antuaneta Buzan1,2, Julien Dinkel3, Christopher Rank4, Claus Peter Heussel2, Marc Kachelrieß 4, Robert Grimm5, and Andreas Wetscherek4,6

1Department of Radiology, Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom, 2Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany, 3Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich, Germany, 4Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 5Siemens Healthcare, Erlangen, Germany, 6Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom

We analyzed the contrast agent late dynamics in fibrotic lung lesions of different severity, assessed with perfusion MRI, using a 5D reconstruction (respiratory 4D at different time points) of a 3D radial stack-of-stars spoiled gradient echo sequence with golden-angle spacing acquired in free-breathing. Idiopathic pulmonary fibrosis (IPF) shows late peak enhancement regardless of severity level and possibly no wash-out within the scan interval, while non-IPF lesions have faster time to peak and slower accumulation rate with increasing severity. The method might prove useful for a more thorough characterization of lung fibrosis burden in the context of new anti-fibrotic treatments available.

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Abstract