Histogram analysis of intravoxel incoherent motion (IVIM) diffusion-weighted MRI (DWI) could be a promising quantitative approach in predicting tumour response to chemoradiotherapy (CRT) in cervical cancer. We retrospectively studied twenty-five patients with cervical cancer who had paired IVIM MRI examinations before and at week-4 of treatment. We observed that histogram skewness of true diffusion coefficient (D) prior to treatment and that a large increase in the 90th percentile of D following CRT were predictive of better CRT response.
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