Abstract #0097

Amide proton transfer magnetic resonance imaging of uterine endometrial cancer: Association with histologic grade

Yukihisa Takayama¹, Akihiro Nishie², Osamu Togao², Yoshiki Asayama², Kousei Ishigami², Yasuhiro Ushijima², Daisuke Okamoto², Nobuhiro Fujita², Kenzo Sonoda³, Jochen Keupp⁴, and Hiroshi Honda²

¹Department of Radiology Informatics and Network, Kyushu University, Fukuoka, Japan, ²Department of Clinical Radiology, Kyushu University, ³Department of Gynecology & Obstetrics, Kyushu University, ⁴Philips Research

The histologic grade of endometrioid adenocarcinoma (EMCA) is one of the important factors in choosing a treatment plan. Currently, needle biopsy or surgical resection is necessary to diagnose the histological grade; a less invasive procedure is strongly desired. In this study, we evaluated the utility of amide proton transfer (APT) imaging in estimating the histologic grade of EMCA. APT signal intensities (SIs) of EMCA increased in accordance with the progression of histologic grade. APT SIs of high-grade EMCA were significantly higher than those of low-grade EMCA. APT imaging has potential as a biomarker for histologic grade of EMCA.

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