Abstract #0080

Effects of RF pulse profile and within-slice phase dispersion on accuracy of MR fingerprinting with balanced SSFP readout

Su-Chin Chiu¹, Te-Ming Lin², Jyh-Miin Lin^3,4, Hsiao-Wen Chung⁵, Cheng-Wen Ko⁶, Martin Büchert⁷, and Michael Bock⁷

¹National Taiwan University, Taipei, Taiwan, ²Radiology, Veterans General Hospital, Taipei, Taiwan, ³Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ⁴Radiology, University of Cambridge, Cambridge, United Kingdom, ⁵Electrical Engineering, National Taiwan University, Taipei, Taiwan, ⁶Computer Science and Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan, ⁷Radiology, University Medical Center Freiburg, Freiburg, Germany

To investigate the effects of within-slice phase dispersion and RF pulse profile on quantitative relaxation mapping using MR fingerprinting with balanced steady-state free precession readout, simulations based on Bloch equations were performed assuming uniform distributions of off-resonance frequency (widths from 0, 1.0, to 2.0 Hz) and imperfect slice profiles of sinc-shaped RF pulses without and with side lobes. Results showed that slight within-slice phase dispersion by 1 to 2 Hz resulted in prominent T2 under-estimations, particularly at large T2 values. Slice profile imperfection led to under-estimations of T1, which became greater as regional off-resonance frequencies increased.

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