Variable Flip Angle (VFA) relaxometry methods have recently been shown to be sensitive to magnetization transfer (MT) induced bias. Common description of this effect relies on a two-pool model (restricted macromolecular pool & visible free water pool). Current practice to restrict influence of MT consists in stretching of RF pulse durations in order to minimize/counter-balance the effect of macromolecular exchange for different flip angle measurements. This work proposes to minimize the estimation bias by using constant saturation MT pulses that simultaneously excite the free-water pool and saturate the restricted-pool creating constant RF-saturation conditions independently of the flip angle (FA) applied.
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