Abstract #0025

7T TOF-MRA Shows Different Patterns of Perforating Artery in Patients with Intracranial Atherosclerosis Disease (ICAD) and Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)

Qingle Kong^1,2, Qi Yang^3,4, Zhaoyang Fan³, Xianchang Zhang^1,2, Yun Yuan⁵, Xiaojing Fang⁵, Jing An⁶, Yan Zhuo¹, and Zihao Zhang¹

¹State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China, ²University of Chinese Academy of Sciences, Beijing, People's Republic of China, ³Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Xuanwu Hospital, Beijing, People's Republic of China, ⁵Department of Neurology, Peking University First Hospital, Beijing, People's Republic of China, ⁶Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, People's Republic of China

7T high-resolution TOF-MRA has the ability to image perforating arteries of middle cerebral artery (MCA). The distribution patterns of orifices in CADASIL (cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy) and ICAD (intracranial atherosclerosis disease) patients are still unclear. In this study, for the first time, we investigated the orientation distribution of perforating artery orifices on MCA trunks using 7T TOF-MRA. Specific features are found in the distribution patterns of orifices in patients with CADASIL, ICAD and healthy volunteers. This technique is promising in the pathological studies of intracranial vascular diseases.

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