Abstract #4492
Heart-Rate Independent, Whole-Heart, Free-Breathing, Quantitative Myocardial BOLD MRI at 3T with Simultaneous 13N-Ammonia PET Validation in Canines
Hsin-Jung Yang 1 , Damini Dey 2 , Jane Sykes 3 , John Butler 3 , Avinash Kali 2 , Ivan Cokic 2 , Behzad Sharif 2 , Sotirios Tsaftaris 4 , Debiao Li 2 , Piotr Slomka 2 , Frank Prato 3 , and Rohan Dharmakumar 2
1
Cedars Sinai Medical Center, Los angeles,
CA, United States,
2
Cedars
Sinai Medical Center, CA, United States,
3
Lawson
Health Research Institute, ON, Canada,
4
IMT
Lucca Institute, Lucca, Italy
Myocardial BOLD MRI is an emerging non-contrast approach
for assessing ischemic heart disease. Current myocardial
BOLD methods are limited by poor spatial coverage,
heart-rate dependency and image artifacts (e.g. coil
bias, B1 and B0 inhomogeneities). To overcome these
limitations, we developed a heart-rate independent,
fast, free breathing 3D T2 mapping technique at 3T that
utilizes near perfect imaging efficiency. This
quantitative BOLD approach, which can be performed
within 3 minutes, permits full LV coverage during
pharmacological stress. In this study, we tested our
approach in a canine model and validated our findings
with simultaneously acquired 13N-ammonia PET perfusion
data in a clinical PET-MR system.
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