Early detection of doxorubicin induced diffuse myocardial fibrosis by contrast enhanced magnetic resonance imaging in rabbit modell: compared with histology and electron microscopy.

Cardiotoxicity of doxorubicin in patients with cancer causes irreversible myocardial damage leading to worse prognosis. To detect early stage of cardiotoxicity, T1 mapping and extracellular volume fraction was tested to determine the feasibility for detection of diffuse myocardial fibrosis in an early stage of cardiotoxicity. There was a good correlation between myocardial ECV measurement and the degree of fibrosis on histology.

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