Abstract #4465
Measurement and quantification of sheep cardiac myocyte and sheetlet orientation from high-field 80 80 160 m contrast-enhanced T1W MRI.
Stephen Henry Gilbert 1 , Julie Magat 2 , Mark Trew 3 , Valery Ozenne 2 , Fanny Vaillant 2 , Jrme Naulin 2 , Olivier Bernus 2 , and Bruno Quesson 2
1
Mathematical Cell Physiology, Max Delbrck
Center for Molecular Medicine, Berlin, Germany,
2
L'Institut
de rythmologie et modlisation cardiaque LIRYC, Pessac,
France,
3
Auckland
Bioengineering Institute, Auckland, New Zealand
We present first high-spatial resolution ex vivo MRI of
myocardial sheetlet structure from a human sized heart
(the sheep heart), obtained at 9.4T/30cm, using a novel
7 elements array coil. This image data allowed us to
reconstruct the ventricular sheetlet and myocyte
orientations using structure tensor image analysis. We
demonstrate that this methodology that has only
previously been applied to small mammalian hearts is
scalable to large animal clinical models. This
methodology allows correlation of explanted myocardial
structure to in vivo and myocardial strain/shear
distributions in large animal clinical models and is
directly applicable to normal/pathologic human hearts
after transplantation.
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