Abstract #4457
Feasibility Analysis of the Chemical Exchange and T 1 Measurement Using Progressive Saturation (CUPS) Method for In Vivo Application to Human Myocardium
David A. Reiter 1 , Mustapha Bouhrara 1 , and Richard G Spencer 1
1
Laboratory of Clinical Investigation,
NIH/National Institute on Aging, Baltimore, MD, United
States
The creatine kinase (CK) reaction is considered to be
important for maintaining ATP supply to demand in the
myocardium over the wide operating range of cardiac
output. The CUPS method has been previously applied to
measurements of chemical exchange rates, such as CK
flux, under preclinical experimental conditions. The
current work uses Cramr-Rao lower bound analysis and
Monte Carlo simulations, targeting in vivo human MRS
conditions for studies of the myocardium at clinical
field strength, demonstrating the feasibility of this
approach for reliable measurement of CK fluxes under a
wide range of experimental and physiological conditions.
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