Abstract #4453
Non-contrast MRI for Assessing Myocardial Fibrosis: Initial Study in a Canine model of Myocardial Reperfusion after Drug Treatments
Jie Zheng 1 , Qian Yin 1 , David Muccigrosso 1 , Ridong Chen 2 , and Dana Abendschein 3
1
Radiology, Washington University School of
Medicine, Saint Louis, Missouri, United States,
2
APT
Therapeutics, Saint Louis, Missouri, United States,
3
Cardiology
Division, Washington University School of Medicine,
Saint Louis, Missouri, United States
A non-contrast MRI fibrosis index method was developed
to consecutively assess myocardial fibrosis in a canine
model after induced myocardial infarction, reperfusion,
and an experimental drug APT102 treatment. In comparison
with controlled study, the fibrosis index demonstrated
similar trend from baseline to 24 hours after APT102
treatments, but dramatically decreased at 7 days. This
was confirmed by histopathological stains in myocardial
tissues.
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