Abstract #4429
Whole post-mortem spinal cord imaging with diffusion-weighted steady state free precession at 7T
Sean Foxley 1 , Jeroen Mollink 1 , Olaf Ansorge 2 , Connor Scott 2 , Saad Jbabdi 1 , Richard Yates 2 , Gabriele De Luca 2 , and Karla Miller 1
1
FMRIB Centre, University of Oxford, Oxford,
OXON, United Kingdom,
2
Nuffield
Department of Clinical Neurosciences, University of
Oxford, Oxford, OXON, United Kingdom
Post-mortem imaging has begun to attract interest as a
method for anatomical investigation that can achieve
higher resolution than in-vivo imaging and be directly
compared against histological gold standards. In this
work we investigate collecting diffusion weighted data
of whole post-mortem human spinal cord at 7T using
diffusion-weighted SSFP. Tractography and fibre
population estimate results demonstrate that
methodological and procedural developments produce high
fidelity data with coherent primary diffusion direction
estimates and significant secondary collateral fibre
estimates. Correlation with PLI data demonstrates the
potential for validating collateral fibre orientations
with MR data.
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