Abstract #4423
Multi-parameter mapping of the human cervical spinal cord in brachial plexus root implantation
Rebecca Sara Samson 1 , Carolina Kachramanoglou 1 , David Choi 2 , Antoine Lutti 3 , David L Thomas 4 , Nikolaus Weiskopf 3 , Olga Ciccarelli 5,6 , and Claudia A M Wheeler-Kingshott 1
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, England, United Kingdom,
2
Spinal
Repair Unit, UCL Institute of Neurology, London,
England, United Kingdom,
3
Wellcome
Trust Centre for Neuroimaging, UCL Institute of
Neurology, London, England, United Kingdom,
4
5Neuroradiological
Academic Unit, Department of Brain Repair and
Rehabilitation, UCL Institute of Neurology, London,
England, United Kingdom,
5
NMR
Research Unit, Department of Brain Repair and
Rehabilitation, Queen Square MS Centre, UCL Institute of
Neurology, London, England, United Kingdom,
6
6NIHR
UCL/UCLH Biomedical Research Centre (BRC), London,
England, United Kingdom
Brachial plexus avulsion (BPA) may lead to paralysis and
anaesthetic of the corresponding arm. Re-implantation of
avulsed ventral roots is an effective surgical technique
that leads to improved motor recovery. The development
of quantitative MRI methods to assess spinal cord tissue
structure following BPA may provide sensitive
non-invasive markers for therapy monitoring. We aimed to
assess whether multi-parameter mapping of the upper
cervical cord (i.e., above the site of injury) detects
pathological changes in patients with BPA who have
received re-implantation, when compared with healthy
subjects. In patients, the relationship between measured
quantitative parameters and clinical outcome measures is
explored.
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