Abstract #4417
Multi-scale coupling of BOLD fMRI and cardiac variability in patients with mild Traumatic Brain Injury
Nathan Churchill 1 , Michael G Hutchison 2 , Doug Richards 2 , Shaylea Badovinac 3 , Marc A Settino 1 , General Leung 4,5 , Gerald R Moran 6 , Todd English 6 , Anthony Sheen 7 , and Tom A Schweizer 8,9
1
Neuroscience Research Program, Keenan
Research Centre for Biomedical Science of St. Michaels
Hospital, Toronto, Ontario, Canada,
2
Concussion
Program, Faculty of Kinesiology and Physical Education,
University of Toronto, Toronto, Ontario, Canada,
3
University
of Toronto, Ontario, Canada,
4
Medical
Imaging, University of Toronto, Toronto, Ontario,
Canada,
5
Keenan
Research Centre, St Michael's Hospital, Ontario, Canada,
6
Siemens
Canada Ltd, Ontario, Canada,
7
Medical Imaging,
St. Michael's Hospital, Ontario, Canada,
8
Neuroscience
Research Program, Keenan Research Centre for Biomedical
Science of St. Michaels Hospital, Ontario, Canada,
9
Faculty
of Medicine (Neurosurgery), University of Toronto,
Ontario, Canada
Traumatic brain injury (TBI) presents a major health
issue, as even mild TBI can lead to significant
impairments. Heart rate variability (HRV) is often used
as a clinical measure of mTBI, indicating autonomic
dysregulation. Recent studies have also demonstrated
that neuronal variability at different time-scales is
related to mTBI. We propose a novel approach of
combining HRV with the neurovascular measures of BOLD
fMRI, to characterize the impact of mTBI. We use
multi-scale wavelet decomposition and measure the
coupling between BOLD signal and HRV across time-scales
using Partial Least Squares, which demonstrates
significant differences between mTBI and control groups.
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