Abstract #4376
Survival prediction of patients with glioblastoma based on combination analysis of mammalian target of rapamycin (mTOR) - epidermal growth factor receptor (EGFR) pathway and dynamic susceptibility contrast (DSC)-MR perfusion imaging
Xiang Liu 1 , Wei Tian 2 , Rajiv Mangla 2 , Mahlon Johnson 2 , and Sven Ekholm 2
1
Department of Imaging Sciences, University
of Rochester Medical Center, Rochester, NY, United
States,
2
University
of Rochester Medical Center, NY, United States
Gliobasltoma, is the most common primary malignant and
fatal brain tumor. The mTOR-EGFR pathway is important
for treatment response and overall survival (OS). Our
translational research found that the molecular
signature of mTOR correlated with maximal rCBV ratio of
peri-enhancing tumor area (rCBVperi-tumor), the patients
with high rCBVperi-tumor had shorter OS, and combination
of rCBVperi-tumor and mTOR could improve prediction of
survival time in patients with glioblastoma.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
