Abstract #4374
Evaluation of demyelination in a new myelin basic protein mutant mouse using in vivo MRI
Tom Dresselaers 1 , Kristof Govaerts 1 , James Dooley 2,3 , Uwe Himmelreich 1 , Adrian Liston 2,3 , and Kim A. Staats 2,3
1
Dept of Imaging and Pathology, KU Leuven,
Leuven, Leuven, Belgium,
2
Autoimmune
Genetics Laboratory, VIB, Leuven, Belgium,
3
Dept.
of Microbiology and Immunology, KU Leuven, Leuven,
Belgium
In this study anatomical imaging and DTI is used to
confirm in vivo the expected demyelination in a novel
myelin basic protein mutant that spontaneously developed
in our colony. Anatomical imaging and T2 relaxometry and
DTI readouts reflect typical changes as also seen in
other demyelination models such as the Shiverer mice.
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