Abstract #4368
Quantification of normal-appearing white matter in Multiple Sclerosis (MS) by quantitative susceptibility mapping (QSM)
Weiwei Chen 1 , Yan Zhang 1 , Wenzhen Zhu 1 , Ketao Mu 1 , Chu Pan 1 , Susan A. Gauthier 2 , and Yi Wang 3
1
Radiology, Tongji Hospital, Tongji Medical
College, Huazhong University of Science& Technology,
Wuhan, Hubei, China,
2
Neurology,
Weill Cornell Medical College, New York, United States,
3
Radiology,
Weill Cornell Medical College, New York, United States
A total of 70 consecutive clinical confirmed MS patients
and 26 age and gender matched healthy controls (HCs) who
underwent quantitative susceptibility mapping (QSM) were
retrospectively selected in this study to assess the
susceptibility of NAWM and its correlation with MS
lesions susceptibility variation and clinical features
in MS patients. This study suggests the following
findings. 1) The NAWM of MS patients showed
significantly higher susceptibility than NWM of HCs. 2)
The NAWM of patients with Gd-enhanced lesions showed a
similar susceptibility to HCs NWM, while the NAWM of MS
patients without Gd-enhanced lesions showed
significantly higher susceptibility than both healthy
controls NWM and the NAWM of patients with Gd-enhanced
lesions. 3) The susceptibility of NAWM was positively
correlated with the increase of MS lesions
susceptibilities.
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