Abstract #4366
Quantify White Matter Damage with Confounding Fiber Crossing and CSF Contamination
Yong Wang 1,2 , Peng Sun 1 , Qing Wang 1 , Kathryn Trinkaus 3 , Robert T. Naismith 4 , Robert E. Schmidt 4 , Anne H. Cross 2,4 , and Sheng-Kwei Song 1,2
1
Radiology, Washington University in St.
Louis, Saint Louis, MO, United States,
2
Hope
Center for neurological Disorders, Washington University
in St. Louis, Saint Louis, MO, United States,
3
Biostatistics,
Washington University in St. Louis, Saint Louis, MO,
United States,
4
Neurology,
Washington University in St. Louis, Saint Louis, MO,
United States
The accuracy of diffusion MRI as biomarkers of white
matter (WM) damage has been significantly compromised by
the presence of fiber crossing and CSF contamination.
Accurate diffusion MRI biomarkers of WM damage requires
to correctly model the effect of crossing fibers and CSF
contamination. Against this background, we demonstrate
the capability of recently developed diffusion basis
spectrum imaging (DBSI) to reliably quantify the
diffusion properties of normal and injured WM tracts
with confounding fiber crossing and CSF contamination.
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