Abstract #4337
Longitudinal MR frequency shift imaging in patients with clinically isolated syndrome
Vanessa Wiggermann 1,2 , Inga Ibs 2,3 , Stephanie M. Schoerner 2,4 , Enedino Hernndez Torres 2,5 , Luanne Metz 6 , David K.B. Li 2,7 , Anthony Traboulsee 5,7 , and Alexander Rauscher 2,5
1
Physics and Astronomy, Univerisity of
British Columbia, Vancouver, BC, Canada,
2
Radiology,
University of British Columbia, Vancouver, BC, Canada,
3
University
of Osnabrueck, Germany,
4
Technical
University of Dortmund, Germany,
5
UBC
MRI Research Centre, Vancouver, BC, Canada,
6
Clinical
Neurosciences, University of Calgary, Calgary, AB,
Canada,
7
Medicine
(Neurology), University of British Columbia, Vancouver,
BC, Canada
Clinically isolated syndrome (CIS) patients experience
demyelinating events, without fulfilling the criteria
for clinically definite multiple sclerosis (MS). Here,
we investigated changes in lesions, normal appearing and
diffusely abnormal white matter in a CIS cohort using MR
frequency shift imaging. Over 2 years no changes were
observed in normal appearing and diffusely abnormal
white matter, while new MS lesions showed changes in the
MR frequency signal before enhancement, a steep increase
during their formation and elevated frequency for 12
months after lesion formation.
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