Abstract #4329
Imaging biomarker and pathophysiology of early memory impairment in multiple sclerosis: a pre-clinical study with diffusion-tensor imaging of hippocampal layers.
Thomas Tourdias 1,2 , Vincent Planche 1 , Bassem Hiba 3 , Aline Desmedt 1 , Gerard Raffard 3 , Aude Panatier 1 , Stphane Oliet 1 , and Vincent Dousset 1,2
1
INSERM U862 Neurocentre Magendie, University
of Bordeaux, Bordeaux, France,
2
Department
of Neuroradiology, Bordeaux University hospital,
Bordeaux, France,
3
UMR CNRS 5536, University
of Bordeaux, Bordeaux, France
Early memory impairment was demonstrated in experimental
autoimmune encephalomyelitis (EAE), the animal model of
multiple sclerosis. High-resolution DTI showed a
selective decrease of FA in the molecular layer (ML) of
the dentate gyrus of the cognitively-impaired EAE-mice
compared to controls. While there was diffuse
hippocampal microglia activation, a selective dendritic
loss and neuronal death in the ML of the dentate gyrus
were the main correlate of the low FA in EAE-mice.
Treatment with the microglia inhibitor minocycline
protected against this neurodegenerative process and
prevented memory impairment; the effect being measurable
as an increase of FA in treated-mice compared to
placebo.
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