Abstract #4320
Correlation between cerebral glutathione, dietary intake and cognitive function in aging and Alzheimers disease
In-Young Choi 1,2 , Jeffrey M. Burns 3 , Debra K. Sullivan 4 , Hung-Wen Yeh 5 , William M. Brooks 1,2 , and Phil Lee 1,6
1
Hoglund Brain Imaging Center, University of
Kansas Medical Center, Kansas City, KS, United States,
2
Neurology,
University of Kansas Medical Center, Kansas City, KS,
United States,
3
Neurology,
University of Kansas Medical Center, Kansas City,
Kansas, United States,
4
Dietetics
and Nutrition, University of Kansas Medical Center,
Kansas City, KS, United States,
5
Biostatistics,
University of Kansas Medical Center, Kansas City, KS,
United States,
6
Molecular
& Integrative Physiology, University of Kansas Medical
Center, Kansas City, KS, United States
Increased generation of free radicals leads to oxidative
damage and changes in antioxidant status and cognitive
function. Thus, a reduction in glutathione (GSH), a
major antioxidant, might be an early event in aging and
neurodegeneration. In this study, we measured the
relationship between cerebral GSH, nutrient intake and
cognitive function in aging and AD using
doubly-selective multiple quantum GSH CSI at 3T. The GSH
levels were significantly lower in AD compared with
age/sex-matched controls and young adults. We also found
a positive correlation of GSH with dairy intake as well
as cognitive function, suggesting the importance of an
adequate antioxidant status.
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