Abstract #4313
Mean Diffusivity as a non-invasive biomarker of the amount of amyloid plaques in Alzheimers disease: a preliminary evaluation in a mouse model.
Matteo Figini 1 , Alessandro Scotti 1 , Ileana Zucca 1 , Emanuela Maderna 2 , Margherita Ruggerone 2 , Marcella Catania 2 , Giuseppe Di Fede 2 , Fabio Moda 2 , Fabrizio Tagliavini 2 , and Maria Grazia Bruzzone 3
1
Scientific Direction, Fondazione IRCCS
Istituto Neurologico "Carlo Besta", Milan, Milan, Italy,
2
Neuropathology
Unit, Fondazione IRCCS Istituto Neurologico "Carlo
Besta", Milan, Italy,
3
Neuroradiology
Unit, Fondazione IRCCS Istituto Neurologico "Carlo
Besta", Milan, Italy
In this work, the potential of diffusion MRI (dMRI)
parameters in the characterization of neuropathological
features of Alzheimers diseases was investigated in a
mouse model. Transgenic mice treated with different
doses of a synthetic peptide were submitted to 7T dMRI
at different time points. A reduction of mean
diffusivity was associated with the deposition of
amyloid plaques highlighted by immunohistochemistry. If
this preliminary result will be confirmed in further
works, mean diffusivity may be an in vivo biomarker of
the amount of amyloid plaques, with applications in the
diagnosis and monitoring of therapy effects on
Alzheimers patients.
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