Abstract #4310
DIFFERENCES IN DMN FUNCTIONAL CONNECTIVITY BEFORE AND AFTER CLINICAL DIAGNOSIS OF AMNESTIC MCI
Eva Manzanedo Senz 1 , Alexandra Cristobal Huerta 1 , Elena Molina Molina 1 , Ana Beatriz Solana 2 , Virginia Mato 1 , Daniel Garca Frank 1 , Eva Alfayate 3 , Juan lvarez-Linera 4 , and Juan Antonio Hernndez-Tamames 1
1
Universidad Rey Juan Carlos, Mstoles,
Madrid, Spain,
2
General
Electric, Munich, Germany,
3
Fundacin
Reina Sofa - Fundacin CIEN, Madrid, Madrid, Spain,
4
Hospital
Rber Internacional, Madrid, Madrid, Spain
Default mode network functional connectivity differences
between amnestic Mild Cognitive Impairment (aMCI)
patients before and after being diagnosed and their
differences with healthy controls (HC) were analyzed in
this work. Two sessions per subject, separated in time
39922 days, were included in the analysis. Our findings
corroborate that DMN functional connectivity impairment
and compensation effects coexist in aMCI compared to HC.
Moreover, the compensation effect is significant at
least one year before aMCI diagnosis and covers larger
areas. Therefore DMN rsfMRI connectivity alterations
could be useful for early detection of aMCI or even of
Alzheimers Disease.
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