Abstract #4272
Cross Sectional and Longitudinal Magnetisation transfer Ratio in Prion disease at 3 Tesla
Enrico De Vita 1,2 , Marie-Claire Porter 3,4 , Ivor Simpson 5 , Zoe Fox 6 , Gerard Ridgway 7 , Sebastien Ourselin 5 , Peter Rudge 3,4 , Diana Caine 3,4 , Rolf Jager 1,2 , Tarek Yousry 1,2 , John Collinge 3,4 , Simon Mead 3,4 , Harpreet Hyare 3,4 , and John S Thornton 1,2
1
Lysholm Department of Neuroradiology,
National Hospital for Neurology and Neurosurgery,
London, United Kingdom,
2
Academic
Neuroradiological Unit, Department of Brain Repair and
Rehabilitation, UCL Institute of Neurology, London,
United Kingdom,
3
MRC
Prion Unit, Department of Neurodegenerative Diseases,
UCL Institute of Neurology, London, United Kingdom,
4
National
Prion Clinic, National Hospital for Neurology and
Neurosurgery, London, United Kingdom,
5
Centre
for Medical Image Computing, University College London,
London, United Kingdom,
6
Education
unit, UCL Institute of Neurology, London, United
Kingdom,
7
Wellcome
Trust Centre for Neuroimaging, UCL Institute of
Neurology, London, United Kingdom
At 1.5T Magnetisation Transfer (MTR) correlated with
clinical severity in inherited prion patients and was
shown to be potentially more sensitive to structural
changes than conventional imaging. We exploited the
higher SNR available at 3T to further elucidate
associations between regional cerebral MTR and disease
progression in prion disease patients scanned serially
(including sporadic, iatrogenic, variant forms alongside
inherited). At baseline patients displayed lower MTR
values in several ROIs vs controls; MTR correlated with
clinical assessment (evaluated using the prion MRC
score). MTR also decreased longitudinally and the rate
of decrease correlated with rate of decrease of MRC
score.
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