Abstract #4270
Comparisons of Neuronal Activations from BOLD and ASL fMRI during an associative working memory task in patients with cognitive normal, mild cognitive impairment, and Alzheimer s Disease
Hyug-Gi Kim 1 , Dan-Bi Kim 2 , Jang-Hoon Oh 1 , Soon Chan Park 2 , Hak Young Rhee 3 , Chang-Woo Ryu 2 , Won-Chul Shin 3 , Dal-Mo Yang 2 , and Geon-Ho Jahng 2
1
Biomedical Engineering, Kyung Hee
University, YoungIn, Gyeonggi-do, Korea,
2
Radiology,
Kyung Hee University Hospital-Gangdong, Seoul, Korea,
3
Neurology,
Kyung Hee University Hospital-Gangdong, Seoul, Korea
To estimate the neuronal activations during an
associative working memory task in patients with
cognitive normal (CN), mild cognitive impairment (MCI)
and Alzheimers diseases (AD), BOLD and ASL fMRI were
studied. The fMRI data during a facename association
encoding task were obtained from 25 CN, 19 MCI, and 23
AD subjects with a block design and with three
conditions (novel, un-novel, and fixation). The
differences of BOLD and ASL fMRI among the three groups
were investigated. We found ASL fMRI was useful to
estimate the significant difference of neuronal
activations for three groups compared to BOLD fMRI.
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