Abstract #4266
T1rho Imaging as a Biomarker for Huntingtons Disease Progression
Vincent Magnotta 1 , Casey Johnson 1 , John Wemmie 2 , Shafik Wassef 1 , Hans Johnson 3 , Jeffrey Long 2 , and Jane Paulsen 2
1
Radiology, University of Iowa, Iowa City,
IA, United States,
2
Psychiatry,
University of Iowa, Iowa City, IA, United States,
3
Electrical
and Computer Engineering, University of Iowa, Iowa City,
IA, United States
Multiple quantitative relaxation parameters (T1ρ, T2,
and T2*) were used to study progression in premanifest
Huntingtons Disease. T1ρ showed the greatest change in
the striatum and was significantly associated with with
disease progression. These changes were also independent
of T2 changes suggesting that the changes were likely
due to changes in chemical exchange. T2* changes were
observed in the globus pallidus but these were not
associated with disease progression. The changes in T1ρ
are consistent with a decrease in glucose concentrations
or pH.
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