Abstract #4246
Quantifying perfusion in conditions of rapidly changing blood flow and vascular volume: A novel tracer kinetic model
Jeff L Zhang 1 , Christopher J Hanrahan 1 , and Vivian S Lee 1
1
Radiology, University of Utah, Salt Lake
City, Utah, United States
DCE MRI is widely used for assessing tissue perfusion
noninvasively, using indicator dilution theory, which
models tissue enhancement as a convolution between the
arterial input function and impulse response function.
This approach requires that the system of interest is
time-invariant during data acquisition, which is
fulfilled in most situations. However, the convolution
approach does not work when perfusion changes
dramatically during the measurement period, such as
skeletal muscle perfusion during exercise-recovery. In
this study, we propose a new tracer kinetic model where
both blood inflow and vascular volume can vary during
the measurement.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
