Abstract #4210
Using the Ratio of T1ρ and T2 MR Parameters to Examine the Relationship Between Anterior Cruciate Ligament (ACL) Abnormalities and Patellofemoral Cartilage Integrity
Nathaniel E. Calixto 1 , Lorenzo Nardo 1 , Deepak Kumar 2 , Richard B. Souza 1 , Xiaojuan Li 1 , Thomas M. Link 1 , and Sharmila Majumdar 1
1
Department of Radiology and Biomedical
Imaging, University of California, San Francisco, San
Francisco, California, United States,
2
Division
of Physical Therapy, College of Health Professions,
Medical University of South Carolina, Charleston, South
Carolina, United States
While T1ρ and T2 MR relaxation times have become
established metrics for cartilage assessment, the T1ρ/T2
ratio could eliminate hydration effects and better
represent macromolecular integrity. A lowered T1ρ/T2
ratio in patellofemoral cartilage was associated with
ACL lesions, consistent with the relationship between
ACL pathology and patellofemoral osteoarthritis. In
subjects with healthy patellofemoral cartilage,
significant T1ρ/T2 ratio differences were observed
between those with and without ACL lesions; no
significant differences were observed with T1ρ or T2
individually, suggesting heightened sensitivity of the
T1ρ/T2 ratio. Future work is necessary to verify the
applicability of the T1ρ/T2 ratio in other anatomy.
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