Abstract #4208
Characterization of [ 18 F]-FDG uptake by hybrid PET-MRI in osteoarthritis of the hip
Audrey P. Fan 1 , Feliks Kogan 1 , Dawn Holley 1 , Andrei Iagaru 1 , Greg Zaharchuk 1 , and Garry E. Gold 1
1
Radiology, Stanford University, Stanford,
CA, United States
[
18F
]-FDG tracer uptake is a potential PET
marker of musculoskeletal inflammation, but its
biodistribution in osteoarthritis (OA) and
colocalization with morphological changes are not well
studied. We characterized [
18F
]-FDG tracer
uptake within different areas of OA joint damage in the
hip identified on simultaneously acquired structural MRI
scans. Twenty patients (mean age = 67 years) were
scanned on a 3T hybrid PET-MR system with time-of-flight
PET and with T2 STIR (short TI inversion recovery) MRI.
An experienced radiologist identified 7 subchondral
cysts and 10 areas of bone marrow lesions (BMLs) on the
MR images. Mean standard uptake value (SUV
mean
)
was highest in joint fluid, which may reflect increased
tracer diffusion or high glucose metabolism due to
inflammation. SUV
mean
was
also elevated in subchondral cysts and BMLs relative to
SUV in normal regions of the femoral head. Our
observations enable improved understanding of [
18
F]-FDG
uptake in normal and diseased joint tissue.
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