Abstract #4201
Microstructural Organization and Macromolecular Contents in Fibrous Tissues of Normal and Hypertensive Eyes with Diffusion Tensor Imaging and Magnetization Transfer Imaging
Leon C. Ho 1,2 , Ian A. Sigal 3 , Ning-Jiun Jan 3 , Tao Jin 1 , Ed X. Wu 2 , Seong-Gi Kim 1,4 , Joel S. Schuman 3 , and Kevin C. Chan 1,3
1
Neuroimaging Laboratory, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Pokfulam, Hong Kong, China,
3
Departments
of Ophthalmology and Bioengineering, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
4
Center
for Neuroscience Imaging Research, Institute for Basic
Science, Sungkyunkwan University, Suwon, Korea
The sclera and cornea are fibrous connective tissues in
the outer coat of the eye which may undergo microscopic
structural realignment and macromolecular changes in
healthy aging and in diseases such as myopia, ocular
hypertension and glaucoma. Recently, we demonstrated the
use of the magic-angle effect to improve MRI sensitivity
to reveal T2 and T2* relaxation changes in scleral and
corneal tissues upon intraocular pressure loading. In
this study, we further evaluated the corneoscleral
shells using high-field DTI and MTI at the magic angle
in order to test the hypotheses that (1) the
microstructural organization and macromolecular contents
of the sclera and cornea can be detected and
differentiated with high-field MRI; and (2) acute ocular
hypertension may alter DTI and MTI properties in these
fibrous tissues.
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