Abstract #4172
T1 Voxel Based Relaxometry for the Local Evaluation of the Knee Cartilage
Valentina Pedoia 1 , Favian Su 1 , Deepak Kumar 1 , Richard Souza 1 , Benjamin Ma 1 , Xiaojuan Li 1 , and Sharmila Majumdar 1
1
UCSF, San Francisco, California, United
States
T1rho MRI quantitative assessment of cartilage
degenerative change is usually addressed through
ROI-based approaches considering T1rho mean as
descriptor. However, previous studies showed that
spatially assessing T1rho using laminar and texture
analyses could lead to better and probably earlier
identification of cartilage matrix abnormalities. Voxel
Based Relaxometry (VBR) is a technique that could
potentially be used for investigating local cartilage
microstructural composition. In this study we show the
use of VBR to study the knee cartilage. VBR showed the
capability to detect specific local patterns of T1ρ
increase that maybe potentially useful for a more
accurate analysis and disease phenotyping
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